3/31/2023 0 Comments Chemotherapy thyroid highcAnaplastic thyroid cancer (ATC), which accounts for less than 2% of thyroid cancer but leads to more than 50% of the annual thyroid cancer-related mortality, remains one of the most aggressive and fatal tumors. Thyroid cancer is a rare malignant tumor that accounts for about 2.9% of all site cancer cases in the USA, with more than 52 thousand newly diagnosed cases and nearly 2,200 new deaths yearly ( 1). RCT should be preferentially applied to ATC patients. Older age, single marital status, surgical resection, distant metastasis, and tumor extension were significant prognostic factors of survival.Ĭonclusions: RCT contributes to prolonged OS and CSS compared with RT alone in ATC patients, regardless of surgical resection and distant metastasis. The prominent effect of RCT versus RT alone remains significant within each subgroup stratified by surgical resection and distant metastasis. As indicated by the inverse probability weighting multivariate regression, RCT was associated with significantly improved OS (adjusted HR = 0.69, 95% CI = 0.56–0.85, p < 0.001) and CSS (adjusted subdistribution HR = 0.77, 95% CI = 0.61–0.96, p = 0.018). The median OS was 4 months and 2 months (IQR 1–4) for patients in the RCT and RT groups, respectively. Results: Of the 491 ATC patients, 321 (65.4%) were in the RCT group and 170 (34.6%) were in the RT group. Subgroup analysis was carried out, and a forest plot was graphed. Multivariate Cox proportional hazard model and Fine-Gray compete-risk model were carried out to investigate prognostic factors relating to overall survival (OS) and cancer-specific survival (CSS). Inverse probability weighting (IPW) was performed to balance variables between the two groups. Methods: Patients with ATC diagnosed between 20 were identified from the Surveillance, Epidemiology, and End Results Program database. We aimed to investigate the effectiveness of RCT versus RT on ATC overall and within subgroups by surgical resection and distant metastasis in a large real-world cohort. 3Department of Radiology and Nuclear Medicine, Shengjing Hospital of China Medical University, Shenyang, Chinaīackground: Whether anaplastic thyroid cancer (ATC) patients benefit more from radiotherapy plus chemotherapy (RCT) than from radiotherapy alone (RT) was controversial.2Department of Health Management, Shengjing Hospital of China Medical University, Shenyang, China.1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.Weili Zhou 1, Yangyang Yue 2 and Xin Zhang 3*
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |